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Editorial
In This Issue
Quentin Rae-Grant
(PDF)


Original Research
Quality of Life in OCD: Differential Impact of Obsessions, Compulsions, and Depression Comorbidity

Mario Masellis, Neil A Rector, Margaret A Richter

(PDF)

A Pilot Study of a Parent-Education Group for Families Affected by Depression
Mark Sanford, Carolyn Byrne, Susan Williams, Sandy Atley, Ted Ridley, Jennifer Miller, Heather Allin

(PDF)

Differentiating Symptoms of Complicated Grief and Depression Among Psychiatric Outpatients
John S Ogrodniczuk, William E Piper, Anthony S Joyce, Rene Weideman, Mary McCallum, Hassan F Azim, John S Rosie

(PDF)

Filicidal Women: Jail or Psychiatric Ward?
Line Laporte, Bernard Poulin, Jacques Marleau, Renée Roy, Thierry Webanck

(PDF)

Phenomenology and Comorbidity of Dysthymic Disorder in 100 Consecutively Referred Children and Adolescents: Beyond DSM-IV
Gabriele Masi, Stefania Millepiedi, Maria Mucci, Rosa Rita Pascale, Giulio Perugi, Hagop S Akiskal

(PDF)

A Multicentre Prospective Controlled Study to Determine the Safety of Trazodone and Nefazodone Use During Pregnancy
Adrienne Einarson, Lori Bonari, Sharon Voyer-Lavigne, Antonio Addis, Doreen Matsui, Yvette Johnson, Gideon Koren

(PDF)


Brief Communication
Clozapine Treatment in Patients With Prior Substance Abuse

Deanna L Kelly, Elizabeth A Gale, Robert R Conley

(PDF)

The Effect of Peer Support on Postpartum Depression: A Pilot Randomized Controlled Trial
Cindy-Lee Dennis

(PDF)


Book Reviews
(PDF)

Psychological Aspects of Women’s Health Care: The Interface Between Psychiatry and Obstetrics and Gynecology. 2nd Edition.
Reviewed by
Vera Lantos, MD, FRCPC

Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques.
Reviewed by
Jimmy Jensen, PhD,
Shitij Kapur, MD, FRCPC, PhD

Planification et évaluation des besoins en santé mentale.
Revue par
Raymond Tempier, MD

Clinical Interaction and the Analysis of Meaning: A New Psychoanalytic Theory.
Reviewed by
Paul Ian Steinberg, MD, FRCPC

Evidence and Experience in Psychiatry. Volume 2: Schizophrenia.
Reviewed by
Mary V Seeman, MD

Schizophrenia Revealed: From Neurons to Social Interactions.
Reviewed by
Emmanuel Stip, MD

How’s Your Marriage? A Book for Men and Women.
Reviewed by
Karl M Tomm, MD FRCPC,
Cynthia A Beck, MD MASc FRCPC

L’extermination des malades mentaux dans l’allemagne nazie.
Revue par
Frédéric Grunberg, MD

Physicalism and Its Discontents.
Reviewed by
Dorian Deshauer, MD FRCP


Letters to the Editor
(PDF)

Zenker’s Diverticulum and Psychosis in the Elderly

Anorgasmia and Withdrawal Syndrome in a Woman Taking Gabapentin

Stage-Oriented Trauma Treatment Using Dialectical Behaviour Therapy

Sexual Sadism With Lust-Murder Proclivities in a Female?

Topiramate-Induced Suicidality

Bright-Light Therapy in Somatization Disorder

Venlafaxine-Induced Delirium

New Dosage-Reduction Regime to Avoid Paroxetine Discontinuation Syndrome

Risperidone-Induced Galactorrhoea: A Case Series

Gamma Hydroxybutyrate Withdrawal in an Orthopedic Trauma Patient

Version française de la Wender Utah Rating Scale (WURS)

A Pilot Study of a Parent-Education Group for Families Affected by Depression


Procedures
Participants were assessed in their home by trained bachelor’s-level research assistants. After they obtained informed consent, the research assistants administered the baseline structured interviews and questionnaires to the participants (and partners who agreed to participate). Selected outcome measures were readministered 2 weeks later. Randomization was carried out after the baseline assessment, by a person independent of the study team. The procedure employed a random numbers table using blocks of 4 (study personnel were blind to blocking). The resulting assignments were placed in numbered, sealed, opaque envelopes that were opened consecutively as participants completed assessment. The group program was mounted within 4 weeks of the baseline assessment. At completion of the group program, experimental and control families completed the questionnaires. Eight weeks later, all participants were again assessed in their home, with measures identical to those used at posttreatment. At the conclusion of the project, an independent research assistant obtained the treatment dropouts’ stated reasons for failure to attend. Treatment groups were run during a 1-year period by leaders (4 nurses, 1 social worker, and 2 leaders with bachelor’s degrees in psychology) who received 2 half-days’ training. Training emphasized close adherence to the manual; however, we did not assess adherence to the treatment model.

Figure 1 provides the sampling results. Of the 65 patients referred to the study, 14 refused to participate and 7 were excluded, leaving 44 participants who were assessed at baseline and randomly assigned to experimental (n = 21) or control (n = 23) conditions. At posttreatment, 32 participants (73%) completed assessment (15 treatment and 17 control subjects), while 12 were lost to assessment. By follow-up, 25 participants (57%) completed assessment, and 19 were missing. Owing to the high loss of participants at follow-up, we did not use data from this assessment. Among the 21 participants assigned to the experimental condition, 7 attended fewer than 2 of 8 sessions. Six parents provided reasons for their failure to attend (2 stated inconvenient timing or location, 2 were attending groups elsewhere, 1 didn’t feel like attending, and 1 stated “mind was racing . . . too much on the go”). To assess whether there was selective loss of participants, we compared those completing the posttreatment assessment with those missed, both in the total sample and separately for the experimental and control groups. For the whole sample, baseline CES-D scores for proband and partner were higher in those lost to assessment than in those assessed (proband mean 38.5, SD 12.4 and mean 29.3, SD 13.6, respectively; partner mean  21.5, SD 16.2 and mean 9.3, SD 9.4, respectively) (t = –1.9, df 40, P = 0.07; and t = –2.3, df 24, P = 0.03, for proband and partner, respectively). There were more single parents among those missed (58% vs 22% in those completing the assessment) (c2 = 5.3, df 1, P = 0.03). When we contrasted experimental and control groups, baseline proband CES-D scores were higher in those lost to assessment than in those assessed in the experimental group (mean 41.0, SD 3.5 vs mean 25.8, SD 13.8) (t = –2.6, df 19, P = 0.02) but not in the control group (mean 35.5, SD 18.6 vs mean 32.7, SD 12.9) (t = –0.4, df 19, P = ns). A similar pattern was seen for partner CES-D. There were more single parents lost at posttreatment in both the experimental and the control groups. These findings show a selective loss of participants with higher depression scores in the experimental group, but not in the control group. Because depressive symptom severity is often associated with a poor response to treatment, this could lead to bias in favour of the experimental group (see below).

Figure 1 Flow Chart of Study Participation

figure1.JPG - 30523 Bytes

Instruments and Measures
Demographics Interview. We interviewed probands and partners for information on income, education level, employment, family structure, and marital status.

University of Michigan CIDI. We used the short-form CIDI to assess whether parents met DSM-IV criteria for major depression in the past year or in their lifetime. In both clinic and community samples, the short-form CIDI is highly sensitive for major depression but has a high false-positive rate (27.3%) (20,21).

The CES-D. This 20-item questionnaire measures depressive symptoms. It is reliable in clinical and population samples, with a = 0.90 and 0.85, respectively, and it discriminates among individuals with depression, normal individuals, and those with other psychiatric disorders (22). Test–retest reliability is higher in clinic than in community samples (estimates range from r = 0.32 to r = 0.67) (23).

Parenting Practices Scale (Modified for Use in the Canadian National Longitudinal Study of Children and Youth [NLSCY]). This 18-item scale measures parenting behaviours. Preliminary factor analyses from NLSCY data for the age group used in this study revealed 3 factors (positive practices, hostile-ineffective practices, and consistency factors) (24). Therefore, in this study, we derived subscale scores for these 3 factors.

Sense of Parenting Competence Scale (Modified for Use in NLSCY) (24). This 11-item scale measures respondents’ sense of competence as a parent.

Family Assessment Device (FAD) (25). The 12-item general functioning subscale of the FAD is a reliable measure of family functioning.

Family Conflict Scale (NLSCY) (24). This 6-item scale measures the level of perceived conflict within the family.

Parent Disagreements Scale (Child Development Supplement, Panel Study of Income) (26). This 9-item scale measures agreement between parents with respect to their performance on frequent parenting practices.

Depression Facts Quiz. This scale assesses knowledge in areas covered by the educational component of the program. The scale from which it was derived detected increases in knowledge about depression in parents of adolescents with depression after they had participated in a psychoeducation program (27).

Health Behaviours Questionnaire and Activities Scale (Ontario Child Health Study) (28). This 15-item scale measures the child’s participation in coached and noncoached activities. There are 3 subscales: competence in sports and arts; level of participation in sports, clubs, arts, and groups; and participation in outside activities with adult leadership.

Peer-Relationships and School-Problems Scales. These 10-item scales were derived from a structured-interview version of the Social Adjustment Inventory for Children and Adolescents (29). The Peer Relationship Scale covers such aspects of peer relationships as having problems in maintaining relationships or having a friend to confide in. The School Problems Scale assesses the presence or absence of school-related problems, such as difficulty completing classwork or difficulty in getting along with teachers. Intraclass correlation coefficients (ICCs) indicated that the test–retest reliability of the parent version was high for the Peer Relationships Scale (ICC = 0.95) and medium for the School Problems Scale (ICC = 0.67) (30).

Children’s Depression Inventory (CDI). This 27-item scale measures depressive symptoms. The scale is reliable, with high test–retest reliability and high internal consistency, and is content-valid (31). The parent-informant version also has high test–retest reliability (32).

Several of the scales had good face validity but lacked adequate psychometric data. Therefore, we assessed internal consistency and 2-week test–retest reliability in this sample. For instruments in which parents rate the same behaviours, we also assessed the level of agreement between parents. Test– retest reliability was medium to high (ICCs ranged from 0.59 for the Parent Disagreements Scale to 0.82 for the Positive Parenting Practices Scale). Similarly, internal consistency was high (that is, a >  0.74) for all scales except for the Depression Facts Quiz, in which a  = 0.42. In contrast, the level of agreement between parents was low to medium. The greatest discrepancies occurred when parents rated family functioning (ICC  = 0.33) and child behaviour (ICCs for CDI scores, competence in sports and arts, participation in activities, and involvement in adult-led activities were 0.2, 0.15, 0.41, and 0.26, respectively).

Statistical Analyses
We employed analysis of covariance (ANCOVA) using “intention-to-treat” analysis to test differences between experimental and control groups in posttreatment outcome measures. This included all participants randomized to treatment or control groups for whom data at baseline and posttreatment were available (n = 32 for these analyses). The baseline value of the dependent variable was entered as a covariate to introduce a control for baseline differences, because there were small (nonsignificant) group differences. We calculated standardized ES when there were significant between-group differences at posttreatment or when differences approached significance (P < 0.10). A second set of ANCOVAs were conducted for variables wherein the significance of the F-value was P < 0.10. In these analyses, proband baseline CES-D score was a second covariate to control for the confounding effect of parental depression severity. We selected the proband CES-D score because there was selective loss of more subjects with depression in the experimental group and because baseline data were complete for this variable. Covariates were restricted to 2, owing to the small sample size.

Results

Table 2 provides means and SDs of family outcome measures, together with the results of ANCOVAs. The F-values of ANCOVAs are displayed in the far right column, as are the ES and F-values for the ANCOVAs that included proband baseline CES-D as a covariate. For proband report, significant between-group differences were found for FAD score (F = 7.6, df 31, P = 0.01). The Family Conflict Scale (F = 3.5, df 31, P = 0.07), Parent Disagreements Scale (F = 3.7, df 23, P = 0.07), and Sense of Parenting Competence Scale (F = 3.7, df 30, P = 0.06) showed trends toward significance (P < 0.1). For these variables, the experimental group showed greater change toward positive functioning. The ES were medium (0.6, 0.6, 0.4, and 0.5 for FAD, Parent Disagreement, Family Conflict, and Sense of Parenting Competence scale scores, respectively). There were no significant differences for the CES-D, Depression Facts Quiz, or Parenting Practices subscale scores. For partner report, there was a trend toward significance for CES-D score (with a lower score in the experimental group) (F = 4.4, df 17, P = 0.05). The ES for this difference was large (ES = 1.3). There were no between-group differences for the remaining variables. The ANCOVAs with proband CES-D as a second covariate consistently reduced effects attributable to treatment grouping, especially for Parent Disagreement and Sense of Parenting Competence. The F-value for the FAD was only marginally lowered (F = 6.6, df 31, P = 0.02).

The between-group differences on the FAD general-functioning scale provide an opportunity to assess the clinical significance of positive findings. This scale has a validated clinical cut-off of 20. At baseline, the mean score by proband for the experimental group was 1 full SD above this cut-off (indicating that 84% exceeded cut-off). By posttreatment, approximately 60% exceeded the cut-off.

Table 3 provides the means and SDs of child outcome measures, as well as the results of ANCOVAs to assess statistical significance of between-group differences at posttreatment. Only the School Functioning Scale score showed a significant between-groups difference (by proband report). Because this was an isolated positive result, no further analyses are reported for these data.

Table 2  Group statistics for parent outcome measures (Mean, SDs, F-values, and significance level)

 

Experimental group
n
= 21


Control group
n = 23


F, (ES)a
[F controlling for CES-D]


Proband report

Baseline
(n = 21)

Posttreatment
(n = 15)

Baseline
(n = 23)

Posttreatment
(n = 17)

Experimental vs control group at posttreatment

Parenting practices:

      Positive

      Hostile-ineffective

      Consistency

Sense of parenting competence

FADb

Family conflict

Parent conflict

Depression facts

CES-Db

 

11.4 (4.2)

13.9 (4.5)

11.2 (3.2)

25.9 (5.4)

27.6 (7.3)

14.6 (3.4)

25.3 (3.6)

19.2 (2.4)

30.1 (13.7)

 

12.1 (3.7)

16.3 (4.4)

14.1 (4.3)

29.9 (5.0)

22.8 (5.0)

16.3 (3.9)

27.1 (3.6)

20.2 (1.9)

22.5 (14.2)

 

11.8 (3.7)

14.5 (5.3)

12.8 (4.7)

26.2 (5.8)

29.7 (8.0)

14.6 (4.0)

22.1 (5.6)

20.0 (2.7)

33.2 (14.0)

 

12.2 (4.2)

16.8 (5.3)

13.4 (4.7)

27.2 (6.4)

29.3 (7.5)

14.7 (3.4)

21.0 (6.5)

20.1 (2.2)

30.2 (11.4)

 

0.3

0.0

2.6

3.7c (0.5) [0.7]

7.6d (0.6) [6.6e]

3.5c (0.4) [0.4]

3.7c  (0.6) [1.5]

0.2

0.9

Partner report

Baseline
(n = 14)

Posttreatment
(n = 10)

Baseline
(n =14)

Posttreatment
(n = 9)

Experimental vs control group at posttreatment

Parenting practices:

      Positive

      Hostile-ineffective

      Consistency

Sense of parenting

      Competence

FADb

Family conflict

Parent conflict

Depression facts

CES-Db

 

9.6 (3.7)

16.6 (4.6)

13.6 (4.4)

30.2 (4.2)

25.9 (5.4)

14.7 (3.7)

23.4 (6.1)

19.6 (2.7)

11.5 (14.4)

 

12.2 (3.1)

19.4 (2.2)

15.1 (3.3)

33.1 (4.1)

22.1 (5.1)

17.4 (2.3)

25.7 (6.3)

19.9 (2.3)

2.6 (3.7)

 

12.2 (5.0)

15.4 (5.9)

12.4 (4.8)

30.9 (5.2)

26.3 (6.1)

14.8 (4.7)

23.1 (5.4)

20.0 (3.5)

12.5 (9.5)

 

10.7 (4.5)

17.2 (5.9)

15.4 (3.2)

31.6 (6.6)

26.5 (8.2)

14.7 (3.9)

23.9 (5.2)

19.3 (2.1)

18.5 (14.6)

 

1.2

0.2

0.7

0.1

0.3

1.3

0.1

0.6

4.4(1.3)

a Standardized effect size (ES) calculated as: difference score experimental group – difference score control group

SD of all baseline scores

bAll scales higher score represents better functioning except for CES-D and Family Functioning

cP < 0.1; dP < 0.01; eP < 0.05



Table 3 Group statistics for child outcome measures (mean, SDs, F-values, and significance level)

 

Experimental group


Control group


F value


Proband report

Baseline
(n = 21)

Posttreatment
(n = 15)

Baseline
(n = 23)

Posttreatment
(n = 17)

Experimental vs control group at posttreatment

Competence in             sports and arts

Participation

Adult-led activity

School functioning

Peer relationships

CDI - Parent Report

6.7 (1.5)

2.6 (1.7)

1.5 (0.7)

7.6 (2.1)

9.5 (5.5)

11.7 (8.7)

6.1 (1.4)

2.1 (1.0)

1.5 (0.7)

8.6 (1.9)

9.8 (5.2)

9.2 (6.3)

6.4 (1.0)

2.5 (2.6)

1.5 (1.1)

7.2 (2.7)

9.0 (4.7)

11.0 (6.9)

6.5 (1.2)

3.0 (4.9)

1.3 (0.6)

7.2 (3.2)

8.7 (4.6)

8.4 (6.3)

1.4

0.9

2.1

1.7

0.1

0.1

Partner report

Baseline
(n = 14)

Posttreatment
(n = 10)

Baseline
(n = 14)

Posttreatment
(n = 9)

Experimental vs control group at Posttreatment

Competence in               sports and arts

Participation

Adult-led activity

School functioning

Peer relationships

CDI–parent report

6.2 (0.8)

1.8 (1.1)

1.2 (0.7)

7.1 (2.4)

9.3 (6.1)

8.5 (6.3)

6.4 (1.0)

2.4 (1.5)

1.8 (0.9)

8.4 (2.0)

7.4 (8.1)

6.7 (7.2)

6.6 (1.5)

2.2 (1.9)

1.3 (0.9)

8.1 (2.3)

7.7 (4.7)

6.6 (4.8)

6.4 (1.0)

1.9 (1.8)

1.4 (0.7)

8.3 (2.2)

6.9 (2.2)

5.2 (3.4)

0.1

0.7

0.4

0.1

0.0

0.4

Discussion

General Findings
Consistent with earlier work (16), this study successfully recruited parents with depression who had children in the target age range. All expressed interest in the program, indicating that they thought an intervention related to parenting issues was relevant. Baseline characteristics showed that the participants suffered clinically significant mood disorders with many current depressive symptoms, high rates of psychiatric hospitalizations, and recurrent illness and treatment by psychiatrists. The CIDI interview did not identify all subjects as having depression in the prior 12 months, which probably reflects lower-than-expected instrument sensitivity. Despite participant interest, there was a high dropout rate beyond randomization. This indicates that barriers to participation need to be understood if the intervention is to be useful to a greater proportion of those in need and to ensure that participants are exposed to an adequate intervention dosage.

A priori, we assumed that, owing to the small sample size, there would be few, if any, statistically significant differences between the treatment and control groups and that medium ES could be taken as preliminary evidence of effectiveness. For the probands, 4 of 9 measures had medium ES at posttreatment, and for 1 measure (FAD), the between-group differences were statistically significant. However, comparison of those missing with those included revealed selective loss of those participants in the experimental group who had higher depressive symptom scores. ANCOVAs controlling for baseline depressive symptoms resulted in reduced F-values for all variables. The FAD scores remained significantly different between groups. These analyses suggest that selective loss of participants with more severe depression contributed to, but did not explain entirely, the superior gains of the experimental group. For partners, the only difference between experimental and control groups at posttreatment was their lower depressive symptom scores. Fewer partners were involved and this could account for the absence of other positive findings for these respondents.

The assessment and treatment-retention problems encountered in the study demonstrate the significant obstacles to undertaking research in this population. It was evident that many of the participating families were highly stressed and that, for these families, there were many competing treatment and social service needs. Even though efforts were made to select a convenient time and location and to provide child care, it was still not possible for some parents to attend. These difficulties will interest those planning trials or clinical interventions for this population; they must be addressed if effective prevention that extends to all affected individuals is to be realized. In this study, participants had lower depressive symptom scores than did dropouts, suggesting that more severe depression acted as a barrier to the intervention. In future, individuals with more severe depression could be offered entry to the program when their depression has improved, although this will not be feasible within the constraints of a clinical trial. Therefore, efficacy trials should exclude referred patients whose depression is simply too severe for them to attend. On a positive note, if the group intervention brings about sustained improvements in family functioning among those who can attend, it will be an important addition to the therapeutic and preventive interventions currently available. Given the different needs of individual families, it is likely that a selection of interventions will be required. Further research is required to develop measures that accurately identify which interventions should be offered according to each family’s specific needs.

Study Limitations
The study had 4 main limitations. First, estimated treatment effects are unreliable, owing to the small sample size and lack of statistical power, which limits the possibilities for hypothesis testing. Second, some of the instruments had limited published psychometric data. This situation arose because of the lack of established measures for many of the dimensions studied. While we addressed this limitation in part by obtaining reliability data within the study, the validity of these measures is not established. Further, the study included no observational measures. This was by choice, given limited staff resources and a lack of readily applied observational tools. These measurement issues affect interpretation of findings: it is impossible to state unequivocally whether one might expect a preventive impact, based on positive changes on study measures. Further work should be directed to identifying observational and self-report measures of parenting and marital and family relations. Some of the instruments used in this study are promising, as they appear to be reliable and sensitive to change. Third, failure to assess fidelity to the intervention means that one cannot be fully confident that the intervention and its described ingredients led to positive family changes. However, the intervention was manualized and had a clear structure, which reduces the likelihood of major variation from the intended program. Finally, data loss owing to dropouts and missed assessments was the most serious study limitation. As discussed already, there is no guarantee that missed experimental subjects were not poor responders to the intervention. If this were the case, it would bias findings toward inflated treatment effects. Readers should assess the study findings keeping in mind that this was an exploratory study with the foregoing methodological limitations.

Conclusions

Findings of positive differences between the treatment and control groups in several areas of family functioning and relationships are promising and indicate that further development and testing of the intervention is warranted. However, the high rate of participant loss, especially among participants with more severe depression, may have contributed to these observed differences. The program could offer advantages for these families over existing preventive programs. Specifically, the program should be more efficient, because several families receive therapy at once. Further, it is structured and manualized, making it readily transferrable to other settings. However, more testing is needed to demonstrate that, with modification, a high rate of participation can be achieved; that it consistently improves family functioning; and that this contributes to better child outcomes, alone or in tandem with child-directed interventions. The program is not suitable for use in clinical settings until these problems and questions are resolved.


Funding Support

This study was completed with the support of a grant from The Hamilton Community Foundation.

Acknowledgements

Special thanks go to Dr Michael Boyle, Canadian Centre for Studies of Children at Risk and Department of Psychiatry and Behavioural Neurosciences, McMaster University, for his review of the paper and comments. The authors also acknowledge the generous support of the families who participated and of the Chedoke Child and Family Centre, Hamilton Health Sciences, for releasing staff to run the groups.

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Manuscript received May 2002, revised, and accepted July 2002.

1. Formerly, Associate Professor, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario; now, Associate Professor, Department of Psychiatry, University of Toronto, Toronto, Ontario.

2. Formerly, Associate Professor, School of Nursing, McMaster University, Hamilton, Ontario; now, Dean, School of Health Sciences, University of Ontario Institute of Technology, Oshawa, Ontario.

3. Assistant Professor, Department of Psychiatry and Behavioural Neurosciencese, McMaster University, Hamilton, Ontario.

4. Facilitator, Mood Disorders Service, Chedoke Child and Family Centre, Hamilton Health Sciences, Hamilton, Ontario.

5. Facilitator, Behaviour Problems Service, Chedoke Child and Family Centre, Hamilton Health Sciences, Hamilton, Ontario.

6. Nurse, Chedoke Child and Family Centre, Hamilton Health Sciences, Hamilton, Ontario.

7. Research Assistant, Chedoke Child and Family Centre, Hamilton Health Sciences, Hamilton, Ontario.

Address for correspondence: Dr M Sanford, Child Psychiatry Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8

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