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Guest Editorial
Needed: Clinical Research in Mood Disorders
Martin Alda, Michael Bauer
(PDF)

In Review
The Antisuicidal and Mortality-Reducing Effect of Lithium Prophylaxis: Consequences for Guidelines in Clinical Psychiatry
Bruno Müller-Oerlinghausen, Anne Berghöfer, Bernd Ahrens
(PDF)

Lithium Augmentation Therapy in Refractory Depression: Clinical Evidence and Neurobiological Mechanisms
Michael Bauer, Mazda Adli, Christopher Baethge, Anne Berghöfer, Johanna Sasse, Andreas Heinz, Tom Bschor
(PDF)

Prophylaxis Latency and Outcome in Bipolar Disorders
Christopher Baethge, Leonardo Tondo, Irene M Bratti, Tom Bschor, Michael Bauer, Adele C Viguera, Ross J Baldessarini
(PDF)

Review Paper
Clinical Features of Bipolar Disorder With and Without Comorbid Diabetes Mellitus
Martina Ruzickova, Claire Slaney, Julie Garnham, Martin Alda
(PDF)

The Cortisol Awakening Response in Bipolar Illness: A Pilot Study
Dorian Deshauer, Anne Duffy, Martin Alda, Eva Grof, Joy Albuquerque, Paul Grof
(PDF)

Implementing Quality Management in Psychiatry: From Theory to Practice—Shifting Focus From Process to Outcome
Brent M McGrath, Raymond P Tempier
(PDF)

Original Research
Mental Disorders and Reasons for Using Complementary Therapy
Badri Rickhi, Hude Quan, Sabine Moritz, Heather L Stuart, Julio Arboleda-Flórez
(PDF)

Readiness to Participate in Psychiatric Research Daniele Zullino, Philippe Conus, François Borgeat, Charles Bonsack
(PDF)

Toward Benchmarks for Tertiary Care for Adults With Severe and Persistent Mental Disorders
Alain D Lesage, Daniel Gélinas, David Robitaille, Éric Dion, Diane Frezza, Raymond Morissette
(PDF)

Brief Communication
Patient Attitudes Regarding Causes of Depression: Implications for Psychoeducation
Janaki Srinivasan, Nicole L Cohen, Sagar V Parikh
(PDF)

Book Reviews
(PDF)

Helping the Helpers Not to Harm: Iatrogenic Damage and Community Mental Health.
Reviewed by
Peter Moore, MD, FRCPC

L’Homme de Vérité.
Revue par
Maurice Dongier, MD, FRCPC

Letters to the Editor
(PDF)

Re: The Combined Use of Atypical Antipsychotics and Cognitive-Behavioural Therapy in Schizophrenia

Reply: The Combined Use of Atypical Antipsychotics and Cognitive-Behavioural Therapy in Schizophrenia

Re: Should Psychologists Be Granted Prescription Privileges? A Review of the Prescription Privilege Debate for Psychiatrists

Reply: Should Psychologists Be Granted Prescription Privileges? A Review of the Prescription Privilege Debate for Psychiatrists

Re: Should Psychologists Be Granted Prescription Privileges? A Review of the Prescription Privilege Debate for Psychiatrists

Reply: Should Psychologists Be Granted Prescription Privileges? A Review of the Prescription Privilege Debate for Psychiatrists

Breath-Holding in Anxiety Disorders

Bright Light, Serotonin Turnover, and Psychological Well-Being

Letters to the Editor

Reply: The Combined Use of Atypical Antipsychotics and Cognitive-Behavioural Therapy in Schizophrenia

Dear Editor:

I thank Dr Opler and colleagues for their comments, and I agree that more work needs to be done to improve our understanding of the interplay between cognitive-behavioural therapy (CBT) and second-generation antipsychotics (SGAs). Dr Opler’s definition of CBT includes teaching or remediating coping skills, cognitive functions, and social adeptness; I have broadly covered this under the domain of cognitive remediation, a part of which involves CBT. The point that SGAs may potentiate the effect of CBT in schizophrenia derives from reports of other medications interfering with CBT (for example, benzodiazepines have a detrimental effect in anxiety disorders, because they impair memory function). Thus if SGAs improve new learning, which in part is the cognitive mechanism involved in CBT, it may be reasonable to hypothesize that SGAs potentiate the effect of CBT. I endorse Dr Opler’s view that CBT and SGAs may target different symptom profiles, but CBT in schizophrenia has been used for positive symptoms, including delusions, somatic passivity, and hallucinations.

Harpreet S Duggal, MD
Pittsburgh, Pennsylvania