Appendix. Toronto Side Effects Scale (TSES)
Within the last two weeks, have you experienced any of the following symptoms? How much trouble did this side effect cause you? (Physician: rate frequency and severity of the symptoms.)
	Frequency					Severity
	Never	Some- times	About half the time	Often	Every- day	No trouble				Extreme trouble
1. Nervousness	1	2	3	4	5	1	2	3	4	5
2. Agitation	1	2	3	4	5	1	2	3	4	5
3.Tremor	1	2	3	4	5	1	2	3	4	5
4.Twitching/myoclonus (muscle contraction)	1	2	3	4	5	1	2	3	4	5
5. Abdominal pain	1	2	3	4	5	1	2	3	4	5
6. Dyspepsia (upset stomach)	1	2	3	4	5	1	2	3	4	5
7. Nausea	1	2	3	4	5	1	2	3	4	5
8. Diarrhea	1	2	3	4	5	1	2	3	4	5
9. Constipation	1	2	3	4	5	1	2	3	4	5
10. Decreased appetite	1	2	3	4	5	1	2	3	4	5
11. Increased appetite	1	2	3	4	5	1	2	3	4	5
12. Weakness or fatigue	1	2	3	4	5	1	2	3	4	5
13. Dizziness	1	2	3	4	5	1	2	3	4	5
14. Postural hypotension (dizzy when getting up)	1	2	3	4	5	1	2	3	4	5
15. Drowsiness/daytime somnolence	1	2	3	4	5	1	2	3	4	5
16. Increased sleep	1	2	3	4	5	1	2	3	4	5
17. Decreased sleep	1	2	3	4	5	1	2	3	4	5
18. Sweating	1	2	3	4	5	1	2	3	4	5
19. Flushing	1	2	3	4	5	1	2	3	4	5
20. Edema (fluid retention)	1	2	3	4	5	1	2	3	4	5
21. Headache	1	2	3	4	5	1	2	3	4	5
22. Blurred vision	1	2	3	4	5	1	2	3	4	5
23. Dry mouth	1	2	3	4	5	1	2	3	4	5
24. Anorgasmia/no orgasm	1	2	3	4	5	1	2	3	4	5
25. Increased libido	1	2	3	4	5	1	2	3	4	5
26. Decreased libido	1	2	3	4	5	1	2	3	4	5
(Men only: items 27–29) 27. Premature ejaculation	1	2	3	4	5	1	2	3	4	5
28. Delayed ejaculation	1	2	3	4	5	1	2	3	4	5
29. Erectile dysfunction	1	2	3	4	5	1	2	3	4	5
30. Other, specify:		2	3	4	5	1	2	3	4	5
	None	£ 2lbs	£ 4 lbs	£ 6 lbs	£ 7 lbs	No trouble				Extreme trouble
31. Weight gain	1	2	3	4	5	1	2	3	4	5
32. Weight loss	1	2	3	4	5	1	2	3	4	5

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