Canadian Psychiatric Association

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Editorial
Mood Disorders—New Definitions, New Treament Directions
Paul Grof
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In Review
"Cade's Disease" and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed Definition for Bipolar Spectrum Disorder
S Nassir Ghaemi, James Y Ko, Frederick K Goodwin
PDF

The Neurobiology of Bipolar Disorder: Focus on Signal Transduction Pathways and the Regulation of Gene Expression
Yarema Bezchlibnyk, L Trevor Young

PDF

Original Research
Major Depression and Its Association With Long-Term Medical Conditions

Lisa M Gagnon, Scott B Patten

PDF

Seasonal Affective Disorders: Relevance of Icelandic and Icelandic-Canadian Evidence to Etiologic Hypotheses
Jóhann Axelsson, Jón G Stefànsson, Andrés Magnússon, Helgi Sigvaldason, Mikael M Karlsson

PDF

Canadian Psychiatric Inpatient Religious Commitment: An Association With Mental Health
Marilyn Baetz, David B Larson, Gene Marcoux, Rudy Bowen, Ron Griffin

PDF

The Moderating Effects of Coping Strategies on Major Depression in the General Population
JianLi Wang, Scott B Patten

PDF

Antidepressant Side Effects in Depression Patients Treated in A Naturalistic Setting: A Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine
JD Vanderkooy, Sidney H Kennedy, R Michael Bagby

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Treatment Delays for Involuntary Psychiatric Patients Associated With Reviews of Treatment Capacity
Michelle Kelly, Sandra Dunbar, John E Gray, Richard L O'Reilly

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Book Reviews
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Books Received

Letters to the Editor
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The Neurobiology of Bipolar Disorder: Focus on Signal Transduction Pathways and the Regulation of Gene Expression



List of abbreviations and acronyms

AC   adenylyl cyclase

ADP adenosine diphosphate

AP 1   activator protein 1

ATP   adenosine triphosphate

ATPase adenosinetriphosphotase

CaM Ca2+/calmodulin

CaMKs CaM-dependent protein kinases

CAMP cyclic adenosine monophosphate

CDNA complementary DNA

CRE cAMP-response element

CREB cAMP-responsive element-binding protein

DAG 1,2-diacylglycerol

DD Differential display

ER endoplasmic reticulum

ERK extracellular signal-regulated kinase

FLMP bacterial peptide

G-proteins guanine-nucleotide binding proteins

GDP guanosine diphosphate

Gpp(NH)p   guanylyl imidodiphosphate

GSK3b   glycogen synthase kinase 3b

GTP   guanosine triphosphate

IMPase   inositol monophosphatase

IP3 inositol 1,4,5-triphosphate

Li lithium

MAPK mitogen-activated protein kinase

MDD major depressive disorder

MNLs mononuclear leukocytes

MRNA messenger ribonucleic acid

P13-kinase phospatidylinositol 3-kinase

PAF platelet activating factor

PGE prostaglandin E

PI phosphoinositide

PIP2 phosphatidylinositol 4,5-bisphosphate

PKA protein kinase A, cAMP-dependent protein
kinase

PKC protein kinase C

PLC phosphatidylinositol-specific phospholipase

PMA phorbol ester

Rap 1 rhoptry-associated protein 1

SAGE serial analysis of gene expression

TRE 12-0-tetradecanolyphorbol-13-acetate-
response element



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