Canadian Psychiatric Association

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Guest Editorial
Eating Disorders
Paul E. Garfinkel
PDF

In Review
Pharmacologic Treatment of Eating Disorders
April J Zhu, B Timothy Walsh
PDF

Psychological Treatments for Anorexia Nervosa: A Review of Published Studies and Promising New Directions
Allan S Kaplan

PDF

Original Research
Acute Psychiatric Inpatient Care for People With a Dual Diagnosis: Patient Profiles and Lengths of Stay

Philip Burge, Hélène Ouellette-Kuntz, Haider Saeed, Bruce McCreary, Dana Paquette, Franklin Sim

PDF

Canadian Geriatric Psychiatrists: Why Do They Do It? A Delphi Study
Susan Lieff, Diana Clarke

PDF

Relation of Blood Counts During Clozapine Treatment to Serum Concentrations of Clozapine and Nor-Clozapine
L Kola Oyewumi, Zack Z Cernovsky, David J Freeman, David L Streiner

PDF

Research Methods in Psychiatry
Breaking Up is Hard to Do: The Heartbreak of Dichotomizing Continuous Data
David L Streiner

PDF

Brief Communciation
Treatment Resistance in Anorexia Nervosa and the Pervasiveness of Ethics in Clinical Decision making
Chris MacDonald

PDF

Topiramate Use in Obese Patients With Binge Eating Disorder: An Open Study
Jose C Appolinario, Leonardo F Fontenelle, Marcelo Papelbaum, Joao R Bueno, Walmir Coutinho

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Book Reviews

The Depressed Child and Adolescent. 2nd ed.

Clinical Assessment of Dangerousness: Empirical Contributions

The Feeling of What Happens: Body and Emotion in the Making of Consciousness

The Evolution of Psychoanalysis: Contemporary Theory and Practice

Psychiatrie gériatrique: esquisse d'une histoire médicale par l'élaboration de son langage

Démystifier les maladies mentales: les troubles de l'enfance et de l'adolescence


Books Received


Letters to the Editor

RE: Who Develops Severe or Fatal Adverse Drug Reactions to Selective Serotonin Reuptake Inhibitors?

RE: Canadian and American Psychiatrists' Attitudes Toward Dissociative Disorder Diagnoses

Acute Onset of Schizophrenia Following Autocastration

The World Trade Center Disaster

Selenium, Thyroid Hormones, Mood, and Behaviour

Relation of Blood Counts During Clozapine Treatment to Serum Concentrations of Clozapine and Nor-Clozapine



References

1. Lieberman JA, Kane JM, Johns CA. Clozapine: Guidelines for Clinical Management. J Clin Psychiatry 1989;50:9–13.

2. Gerson SL, Meltzer H. Mechanisms of clozapine-induced agranulocytosis. Drug Safety 1992;7 (Suppl.1):17–25.

3. Pisciotta AV, Konings SA, Ciesemier LL, Cronkite CE, Lieberman JA. On the possible mechanisms and predictability of clozapine-induced agranulocytosis. Drug Safety 1992;7 (Suppl.1):33–44.

4. Veys PA, Wilkes S, Shah S, Noyelle R, Hoffbrand AV. Clinical experience of clozapine- induced neutropenia in the UK: laboratory investigation using liquid culture systems and immuno-fenorocytometry. Drug Safety 1992;7 (Suppl. 1):26–32

5. Gerson SL, Arce C, Meltzer HY. N-desmethyl clozapine: A clozapine metabolite that suppresses Haemopoiesis. Br J Hematol 1994;86:555–61.

6. Centorrino F, Baldessarini RJ, Flood JG, Kando JC, Frankenburg FR. Relation of leucocyte counts during clozapine treatment to serum concentration of clozapine and metabolites. Am J Psychiatry 1995;152:610–2.

7. Freeman DJ, Li MC, Oyewumi LK. Solid-phase extraction and HPLC analysis of clozapine and nor-clozapine in human plasma. Ther Drug Monit 1996;18:668–92.

8. Choc MG, Lehr RG, Hsuan F, Honigfeld G, Smith HT. Multiple dose pharmacokinetics of clozapine in patients. Pharmaceutic Res 1987;4:402–5.

9. Krupp P, Barnes P. Clozapine-associated agranulocytosis: risk and aetiology. Br J Psychiatry 1992;160 (Suppl 17):38–40.

10. Uetrecht JP. Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis. Drug Safety 1992;7 (Suppl 1):51–6.


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Manuscript received April 2001, revised, and accepted February 2002.

1 Professor of Psychiatry, Queen’s University, Kingston, Ontario.

2 Professor of Psychiatry, University of Western Ontario, London, Ontario.

3 Associate Professor, Faculty of Medicine, University of Western Ontario, London, Ontario.

4 Director, Kunin-Lunefeld Applied Research Unit, Toronto, Ontario.

Address for correspondence: Dr LK Oyewumi, Hotel Dieu Hospital, 166 Brock St, Kingston, ON K7L 5G2

e-mail: oyewumik@post.queensu.ca