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Editorial
The Role of Pharmaceutical Companies in Research and Development — Plaudits and Cautions
Quentin Rae-Grant
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Guest Editorial
Diagnostic Concepts and the Prevention of Schizophrenia
Ming T Tsuang, Stephen V Faraone
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In Review
Understanding Predisposition to Schizophrenia: Toward Intervention and Prevention
Ming T Tsuang, William S Stone, Stephen V Faraone
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Preventing Schizophrenia and Psychotic Behaviour: Definitions and Methodological Issues
Stephen V Faraone, Hendricks Brown, Stephen J Glatt, Ming T Tsuang

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Original Research
Association of QEEG Findings With Clinical Characteristics of OCD: Evidence of Left Frontotemporal Dysfunction

Ôenel Tot, Aynur Özge, Ülkü Çömelekolu, Kemal Yazici, Nilgün Bal

(PDF)

Ecstasy and Drug Consumption Patterns: A Canadian Rave Population Study
Samantha R Gross, Sean P Barrett, John S Shestowsky, Robert O Pihl

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Research Methods in Psychiatry
The 2 “Es” of Research: Efficacy and Effectiveness Trials

David L Streiner,

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Brief Communication
Serum Cholesterol Level Comparison: Control Subjects, Anxiety Disorder Patients, and Obsessive–Compulsive Disorder Patients

Helmut Peter, Iver Hand, Fritz Hohagen, Anne Koenig, Olaf Mindermann, Frank Oeder, Markus Wittich

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Perceptions of Intimidation in the Psychiatric Educational Environment in Edmonton, Alberta
Phil Tibbo, CJ de Gara, Treena M Blake, Carolyn Steinberg, Brian Stonehocker

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Senior Residents in Psychiatry: Views on Training in Developmental Disabilities
Philip Burge, Hélène Ouellette-Kuntz, Bruce McCreary, Elspeth Bradley, Pierre Leichner

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Evidence That Latitude is Directly Related to Variation in Suicide Rates
George E Davis, Walter E Lowell

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CPA Position Paper
The 1996 CMA Code of Ethics Annotated for Psychiatrists

 


Book Reviews
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Substance Abuse Treatment and the Stages of Change: Selecting and Planning Interventions.

Handbook of Personality Disorders: Theory, Research and Treatment

A Clinical Guide to Sleep Disorders in Children and Adolescents

Love Relations: Normality and Pathology

The Mental Health Matrix: A Manual to Improve Services


Letters to the Editor
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Massive Weight Gain and Hostility Force Mirtazapine Stoppage

Functional Dyspepsia and Mirtazapine

Re: Using Language in Psychiatry

Dr Fine Replies

Psychotic Mania in Bipolar II Depression Related to Sertraline Discontinuation

Délirium associé à l’azithromycine

Behavioural Therapy for the Treatment of Alcohol Abuse and Dependence

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Results

Questionnaires were completed by 80 women (38.8%) and 126 men (61.2%), with 4 participants not indicating their sex. Statistical analyses were based on 11 of the drugs surveyed; we omitted heroin because only 8 respondents had used it. Participant ages ranged from 16 to 32 years (mean 21.4 years, SD 3.18). In all analyses, we considered sex and event attended; however, no significant interaction effects were found. Drug histories are summarized in Table 1.

Progression of Drug Use

Average age of first use for alcohol was 14.05 years (SD 2.18, n = 188), for cannabis 15.13 years (SD 2.59, n = 192,) and for nicotine 14.21 years (SD 2.34, n = 63), which identified these drugs as potentially the first 3 steps in drug experimentation (see Table 1).

To accommodate the data that fit a block design with missing values, we used a univariate analysis of variance to calculate significant differences between the means of age of first use. We treated subjects independently to account for variability in the number of different drugs used by each participant. We found an overall significant difference between mean age of first use and the particular drug used (F = 60.125, P < 0.001). We than applied Bonferroni and Tukey honestly significant difference (HSD) contrasts to identify specific significant mean differences. We found significant mean differences with the following subsets, defined using harmonic mean sample sizes and an alpha level of 0.05: 1) alcohol, nicotine, and cannabis; 2) cannabis, LSD, and psilocybin; 3) amphetamine, cocaine, MDMA, GHB, ephedrine, and ketamine. Based on overall significance, a rank order for progression can be inferred, which indicates the following linear trend in progression of first use: 1) alcohol, 2) nicotine, 3) cannabis, 4) LSD, 5) psilocybin, 6) amphetamine, 7) cocaine, 8) MDMA, 9) GHB, 10) ephedrine, and 11) ketamine.

To test for linear and quadratic trends, we also applied a repeated-measures analysis of variance (ANOVA) to the data on drugs used by more than 25% of the sample. While this analysis yields results only for those subjects who used all the listed substances (n = 44), we found a similarly significant linear trend for the experimentation order: 1) alcohol, 2) cannabis, 3) LSD, 4) psilocybin, 5) amphetamine, 6) cocaine, 7) MDMA (F = 304.8, < 0.001). To further delineate these trends, we employed a correlational analysis using the nonparametric Spearman’s rho to account for monotonic relations between variables. We found significant positive correlations at the 0.01 level between the age of first use of alcohol and cannabis, cocaine, amphetamines, ephedrine, GHB, psilocybin, MDMA, nicotine, and LSD. As well, we found significant positive correlations between age of first use of cannabis and age of first use of all drugs except ketamine. After we applied a Bonferroni correction, significant relations were maintained for all except the alcohol-to-amphetamine, -ephedrine and -GHB correlations and the cannabis-to-GHB and -ephedrine relations.

Total Number of Lifetime Uses

Table 1 indicates the percentage of the subjects who had used each drug.

Although mean computations suggest the highest use for cannabis (mean 1088.4) and alcohol (mean 361.2), it is important to note that we did not collect lifetime estimates of tobacco consumption. When median scores are calculated to account for outliers in the data, alcohol (median 100) and cannabis (median 150) remain the most frequently used substances.

We conducted bivariate correlations using the nonparametric Spearman’s rho to determine relations among the number of lifetime uses for different drug types. After we applied a Bonferroni statistical correction, we found significant relations (P < 0.01) for the following groupings: alcohol lifetime use correlated with cannabis lifetime use; amphetamine lifetime use with MDMA lifetime use; cannabis lifetime use with psilocybin lifetime use; and LSD lifetime use with psilocybin lifetime use.

Number of Uses in Preceding 30 Days

Table 1 reports what percentage of subjects who had reported at least 1 use of a particular drug had used that drug in the preceding 30 days, as well as the mean number of uses for each drug during this time period. Listed in descending order according to percentage of recent recurrent users, the drugs rank as follows: alcohol, cannabis, amphetamine, MDMA, ketamine, ephedrine, GHB, psilocybin, and LSD.

Median scores were also considered, to account for extreme users. With these scores, cannabis is notable as the most frequently consumed drug during the preceding 30 days (median 15), followed by alcohol (median 5).


Discussion

Our study sought to clarify the drug-consumption patterns of Montreal youth who attend raves. Research on this population suggests that rave attendees represent a significant proportion of illicit drug users. Our findings confirm that members of this group take greater quantities and experiment with a greater variety of substances than do their peers who do not attend raves (21–27).

To determine whether there was a general pattern of stepwise drug experimentation, we applied 2 different statistical analyses to the data. We identified the following progressive pattern: 1) alcohol, 2) nicotine, 3) cannabis, 4) LSD, 5) psilocybin, 6) amphetamine, 7) cocaine, 8) MDMA, 9) GHB, 10) ephedrine, and 11) ketamine. It is notable that the substances used by more than 10% but less than 25% of this population appeared as the last 3 in the sequence of experimentation. A similar study in Norway determined the following best-fit for the progression pattern: 1) alcohol, 2) cigarettes, 3) cannabis, 4) amphetamines 5) ecstasy, and 6) heroin (28). Despite the fact that this was a normal population survey, and questions on hallucinogen use were not incorporated, the overall similarities with our findings are striking.

The sample used alcohol and cannabis substantially. Overall, 89.5% of the subjects reported prior intoxication with alcohol, 69.7% of these in the past 30 days. Similarly, 91.4% of those surveyed reported having used cannabis, 67.7% of these in the previous 30 days. Interestingly, the early use of either substance was associated with an early use of cocaine, psilocybin, LSD, and MDMA, suggesting their potential as possible “gateway” drugs.

While MDMA was the third most commonly used drug in this sample, the age of first use appeared later (that is, 8th) in the drug experimentation sequence than had been anticipated. As well, the lifetime uses and uses in the preceding 30 days were also lower than had been expected. MDMA, however, is still among the most prevalent drugs consumed at raves. Indeed, the high prevalence of MDMA use found in this study is consistent with research findings in rave samples surveyed in Australia (76%) (29). Since rave events typically occur on weekends, however, occasion to take MDMA may be regarded as less frequent than occasion for consuming substances such as alcohol or cannabis.

The prevalence of amphetamine use, including both recent and overall consumption, was comparable to that of MDMA. It was the third most popular drug for use in the preceding 30 days: 47.6% of those surveyed reported amphetamine use, slightly exceeding the 40% reporting MDMA use during this period. Further, while 73.3% of the overall sample reported ever using amphetamine, a comparable 75.2% reported MDMA lifetime use. These findings suggest that, in addition to MDMA, amphetamine should be examined as a primary drug used by rave populations.

The use of the hallucinogenic drugs LSD and psilocybin was also reported by a substantial portion of the sample (56.2% and 70%, respectively). Although participants reported initially experimenting with these drugs at a relatively early age, most users did not report consuming them in the preceding 30 days (22% reported pilocybin use, and 12.7% reported LSD use). These findings suggest that while the use of hallucinogenic drugs often precedes the consumption of drugs like MDMA and amphetamine, these drugs are seldom in active use by individuals attending raves. It is interesting to note that while the level of LSD use was positively associated with the level of psilocybin consumption, using these drugs did not reliably predict the subsequent level of MDMA or amphetamine use, suggesting a limited role for hallucinogens as gateway drugs in a rave population.

Several drugs, including ketamine, GHB, and ephedrine, did not surface as popular substances within this sample, each having been used by fewer than 25% of those surveyed. Nevertheless, approximately one-third of those who had experimented with these drugs had done so recently. It seems plausible that the apparent infrequent use of these 3 drugs is related to their late introduction into the typical sequence of drug experimentation.

Although this study identifies the drug-consumption patterns and histories of individuals who attend Montreal-area raves, it is appropriate to address some of the investigation’s possible limitations. Because this study relied on retrospective recall, the accuracy of such reports might be questioned. However, it should be noted that the research question precludes prospective data collection and that the methods used are in accord with abundant published reports that use a similar methodology (for example, 27–29). In addition there are several indications that substance use self-report data can be both reliable and valid (for example, 30,31).

A second issue involves the degree to which this moderate sample can accurately reflect the drug-taking patterns of Montreal rave attendees in general. Because the participants were self-selected for this investigation, it is possible that they do not represent the group as a whole. Although we attempted to minimize this by administering questionnaires at 3 separate events and found no significant differences among these subgroups, only a random sample of rave attendees would ensure the generalizability of these findings. Nevertheless, the present results are consistent with findings obtained from other samples of drug users (for example 28,29). As well, since an entire generation of ages was surveyed (range 16 to 32 years), this study potentially captured both long-term and relatively new partygoers.


Funding and Support

SP Barrett was supported by a scholarship from the Canadian Institutes of Health Research. RO Pihl was supported by Canadian Institutes of Health Research, grant MT-9980.


Acknowledgments

The authors acknowledge Jean-Sebastian Fallu and the “Groupe de Recherche et d’Intervention Psychosociale” for their assistance in data collection.

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