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Editorial
Mood Disorders—New Definitions, New Treament Directions
Paul Grof
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In Review
"Cade's Disease" and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed Definition for Bipolar Spectrum Disorder
S Nassir Ghaemi, James Y Ko, Frederick K Goodwin
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The Neurobiology of Bipolar Disorder: Focus on Signal Transduction Pathways and the Regulation of Gene Expression
Yarema Bezchlibnyk, L Trevor Young

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Original Research
Major Depression and Its Association With Long-Term Medical Conditions

Lisa M Gagnon, Scott B Patten

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Seasonal Affective Disorders: Relevance of Icelandic and Icelandic-Canadian Evidence to Etiologic Hypotheses
Jóhann Axelsson, Jón G Stefànsson, Andrés Magnússon, Helgi Sigvaldason, Mikael M Karlsson

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Canadian Psychiatric Inpatient Religious Commitment: An Association With Mental Health
Marilyn Baetz, David B Larson, Gene Marcoux, Rudy Bowen, Ron Griffin

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The Moderating Effects of Coping Strategies on Major Depression in the General Population
JianLi Wang, Scott B Patten

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Antidepressant Side Effects in Depression Patients Treated in A Naturalistic Setting: A Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine
JD Vanderkooy, Sidney H Kennedy, R Michael Bagby

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Treatment Delays for Involuntary Psychiatric Patients Associated With Reviews of Treatment Capacity
Michelle Kelly, Sandra Dunbar, John E Gray, Richard L O'Reilly

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Book Reviews
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Books Received

Letters to the Editor
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The Moderating Effects of Coping Strategies on Major Depression in the General Population



Methods

In the 1994–1995 NPHS, subjects who were age 18 years or over and resided in Alberta at the time of interview (n = 1039) provided information about major depression and how the subjects dealt with stress from unexpected and difficult problems related to family and personal crises. Table 1 presents the questions related to coping strategies. Subjects might have offered either a “Yes” or “No” answer to each of those questions. A “Yes” answer was considered evidence that the subject used this coping strategy to deal with unexpected family problems and personal crises in this analysis.

In the NPHS, major depression was measured using the Composite International Diagnostic Interview-Short Form (CIDI-SF) for major depression, developed and validated by Kessler and colleagues (15). Major depression, as defined in the NPHS, represents a 90% predictive cut-point for the CIDI-SF (14). This cut-point corresponds to reporting 5 of 9 DSM-IV diagnostic criteria for major depression (the number of symptoms required to make the diagnosis) during the same 2-week period in the past 12 months, and at least 1 of which must be depressed mood or loss of interest (16). Therefore, using this cut-point has its face validity for the DSM-IV criterion A for major depression. The sensitivity and specificity of the CIDI-SF ranged between 90% and 94% in studies conducted by Kessler and colleagues (15). However, the CIDI-SF does not contain probe questions to determine whether depressive symptoms are due to substance use, physical illness, and bereavement. The CIDI-SF development and validation documents showed that organic exclusions were used in the empirical work to select the scale items and were considered in generating the possibilities of caseness (http://www.who.int/msa/cidi/cidisfscoring.pdf). However, a recent validation study using a community sample suggested the CIDI-SF might pick up a broader spectrum of depressive morbidity than would major depression as strictly defined using the full version of CIDI (17). About 75% of subjects scoring 5 or more on the Composite International Diagnostic Interview-Short Form for Major Depression (CIDI-SFMD) had major depression according to the full CIDI.

In this analysis, stresses were identified by identifying those subjects who reported 1 or more recent life events or chronic stress. The NPHS used 17 questions to measure chronic stress in 7 dimensions: personal stress, financial stress, relationship stress (with a partner), relationship stress (no partner), environmental stress, child problems, and family health stress. Tables 2 and 3 present the questions used to measure recent life events and chronic stress. Again, subjects might have offered either a “Yes” or a “No” answer to each of these questions. In this analysis, logistic regression models were used to detect interaction effects between stress and various coping strategies on major depression prevalence. All analyses were performed in men and in women separately. Since the NPHS used a complex sampling design, the estimates of this analysis were weighted to account for sampling procedures.

Because we examined the impacts of 8 different coping strategies on the association between stress and the prevalence of major depression, multiple comparison problems presented. To address this issue, we used Bonferroni’s correction in this analysis. Specifically, the significance level was set at 0.006 (0.05/8 = 0.00625) in the current analysis. The results of statistical tests, above this level were considered not significant. Although Bonferroni’s correction is simple and applicable in any multiple test situation, the weakness of Bonferroni’s correction is low power (18). Therefore, Bonferroni’s correction should be considered a conservative strategy for adjusting the multiple comparison problem.

Results

To evaluate the moderating effects of reported coping strategies on the associations between stresses and major depression, interaction terms involving the specific stress and coping responses were fitted into a series of logistic regression models. Table 4 illustrates the significant results with Bonferroni’s correction. As seen from this table, when exposed to financial stress, using “pray or seek religious help” as a coping strategy alleviated the risk of major depression for women. In addition, when women were exposed to relationship stress (with a partner), those who reported using “talk to others about the situation” as a coping strategy were found to have a lower risk of major depression than did other women.

Table 5 lists the results that were significant at the level of 0.05. The data suggested that, when subjects were exposed to 1 or more recent life events, women who reported using “try not to think about it” or “expressing emotion” as a coping strategy might have a lower risk of major depression than did other women. The former strategy could be loosely characterized as avoidance. The data also suggested that using “talk to others about the situation” as a coping strategy moderates the risk of major depression to a lower degree for men when they reported 1 or more recent life events. Women who used “expressing emotion” as a coping strategy to deal with personal stress appeared to be at a lower risk of major depression. This finding was not observed among men. When exposed to financial stress, using problem-solving strategies (“try to do something to change the situation”) as a coping mechanism seemed to decrease the risk of major depression for men. When exposed to relationship stress (with and without a partner) and environmental stress, using “expressing emotion” might decrease the risk of major depression among women. The data provided no evidence that the reported coping strategies moderated the risk of major depression for men dealing with relationship and environmental stresses. One unexpected finding of this part of the analysis was that reported use of “try to see the situation differently” as a coping strategy might be associated with an increased prevalence of major depression for those women who were not married or without partners when they dealt with relationship stress.

Discussion

In this analysis, none of the reported coping strategies were found to have a general moderating effect on the association between major depression prevalence and all of the stressors evaluated. This finding suggests people’s coping strategies may differ with stressful situations, and certain coping strategies may moderate the effect of specific types of life stress on major depression risk or prognosis—but not necessarily to the same extent for both sex groups. This finding is consistent with the current view that coping strategies are situation- -specific. That is, the same coping strategy may be helpful or counterproductive, depending on the dimensions of challenge (19).

 

Some individuals may use maladaptive coping styles to deal with a life event or hassle, which may intensify the depressive symptoms (3,20).

Using “pray or seek religious help” may decrease the risk of major depression due to financial stress, and “talk to others about the situation” regarding relationship stress may reduce the risk of major depression for women. So far, only 1 study has investigated the impact of religiosity on the associations between depressive symptoms and various life stressors (21). In that study, Strawbridge and others reported that involvement in organized and nonorganized religious activities buffered the association between depressive symptoms and nonfamily stressors such as financial and health problems among elderly people (aged 50 to 102 years) (21). It is possible that women who have financial stress and who are religious may not only receive spiritual comforts but may also receive tangible help from others in the religious group, thus leading to a decreased risk of major depression. With respect to the effect of using “talk to others about the situation” as a coping strategy, Fuhrer and others (22) reported that women have more close personal relationships than do men, although men have larger social networks in the Whitehall II study. Therefore, in the NPHS, women who reported relationship stress with a partner and who use “talk to others about the situation” as a coping strategy may more likely share their problems with close friends and be comforted by these friends.

The mechanisms underlying the sex-specific effects of reported coping strategies such as “talk to others about the situation” and “pray and seek religious help” on major depression prevalence were not clear. Men were less likely than women to report using these 2 coping strategies in the NPHS. Detailed studies using more highly developed methods evaluating coping are necessary to replicate these findings and to delineate why certain coping strategies affect men and women to different extents in reducing the effects of life stressors on major depression.

Previous studies have reported that expressing emotion was associated with an increased level of depressive symptoms for women (9,23). In a Finnish adolescent sample, Hanninen and Aro (24), found that using emotional discharge as a coping strategy increased the levels of depressive symptom (measured by Beck Depression Inventory [25]) for young girls when exposed to life stress. In our analysis, it was found that using “expressing emotion” as a coping strategy might moderate the effects of recent life events, personal stress, relationship stress (with a partner), and environmental stress on major depression for women, but not for men. These differences might be due to the instruments used to measure depression, the definition of emotional expression, and the samples used in the different studies. In Hanninen and Aro’s study, emotional discharge included venting anger, self-blaming, smoking, and drinking—and these items were positively associated with depressive symptoms (25). Further, we considered that these differences could also be due to the buffering effect of social support because women were more likely to use “talk to others about the situation” as a coping strategy. In fact, a longitudinal study using university students (26) reported findings consistent with ours, that is, emotion-focused coping including emotional expression benefitted women in that it reduced depressive symptom levels when they were exposed to life stress. Some researchers have concluded that emotional expression may enhance adjustment when exposed to life stress by facilitating change in cognitive-affective schema, releasing inhibited physiological and psychological tension, and motivating adaptive behaviour (27,28). The moderating effect of “expressing emotion” on the association between various stresses and major depression was considered not statistically significant after Bonferroni’s correction in this analysis. We need to confirm these findings in future studies.

Because the subjects in this analysis consisted exclusively of those who resided in Alberta at the time of interview, specific social context might impact on the associations observed in this analysis. Thus, these findings should be extrapolated with caution. Moreover, this analysis consisted of subjects who were exclusively age 18 years and over at the time of the interview. Hence, the results might not apply to the younger population.

One of the limitations, however, was that this analysis relied on self-reported information. Subjects might either overreport or underreport their coping strategies. Nevertheless, the impact of reporting bias on the results of this analysis could not be examined directly using the existing data. Another limitation of this analysis was that the CIDI-SFMD is a brief indicator of major depression that may not be as sensitive as the full version of CIDI. Unlike previous studies asking detailed questions about coping strategies, the NPHS questions about coping strategies are rudimentary in nature. These questions are relatively crude and could not necessarily capture or measure all aspects of coping. Consequently, the findings of this analysis should be considered preliminary.

This analysis was cross-sectional. Causal relations could not be drawn from this analysis because having a depressive disorder could impact upon self-reported coping strategies. Longitudinal studies will be necessary to clarify this and other temporal effects. Although NPHS contained a longitudinal component, due to a small sample size, the estimates based on this longitudinal component were not sufficiently precise to support this type of analysis. Further, the NPHS is a general-population health survey, and measures sufficiently accurate to fully address such issues were not included in the interview. The advantage of reporting the NPHS data is that it is population-based, providing some insights into the experiences of members of the general population.

Major depression is a heterogeneous condition influenced by biological, psychological, and social factors. Recent studies of the efficacy of brief counselling in the primary care context—particularly those forms of counselling that focus on enhanced coping—suggest that these approaches are efficacious, at least for mild depressive episodes (29–32). We need detailed clinical studies to develop and refine these strategies. Nevertheless, the data presented here provide some epidemiological confirmation of the importance of coping strategies in relation to stress as determinants of mood disturbances in the population.