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Editorial
Mood DisordersNew
Definitions, New Treament Directions
Paul Grof
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In Review
"Cade's
Disease" and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed
Definition for Bipolar Spectrum Disorder
S Nassir Ghaemi,
James Y Ko, Frederick K Goodwin
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The Neurobiology
of Bipolar Disorder: Focus on Signal Transduction Pathways and the
Regulation of Gene Expression
Yarema Bezchlibnyk, L Trevor Young
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Original
Research
Major Depression
and Its Association With Long-Term Medical Conditions
Lisa M Gagnon, Scott B Patten
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Seasonal Affective
Disorders: Relevance of Icelandic and Icelandic-Canadian Evidence
to Etiologic Hypotheses
Jóhann Axelsson, Jón G Stefànsson,
Andrés Magnússon, Helgi Sigvaldason, Mikael M Karlsson
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Canadian Psychiatric
Inpatient Religious Commitment: An Association With Mental Health
Marilyn Baetz, David B Larson, Gene Marcoux, Rudy
Bowen, Ron Griffin
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The
Moderating Effects of Coping Strategies on Major Depression in the
General Population
JianLi Wang, Scott B Patten
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Antidepressant
Side Effects in Depression Patients Treated in A Naturalistic Setting:
A Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine
JD Vanderkooy, Sidney H Kennedy, R Michael Bagby
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Treatment
Delays for Involuntary Psychiatric Patients Associated With Reviews
of Treatment Capacity
Michelle Kelly, Sandra Dunbar, John E Gray, Richard
L O'Reilly
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Book Reviews
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Books Received
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Letters to the Editor
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Letters to the Editor
Re: Short-Term Dynamic Psychotherapies in the Treatment of Major Depression
Dear Editor:
We thank Dr Abbass for his comments on the Clinical Guidelines for the
Treatment of Depressive Disorders and his attention to short-term dynamic
psychotherapies (STDPs), which he contends have a sufficient evidence
base to be a first-line psychotherapy treatment.
We are grateful to him for drawing attention to Leichsenrings recent
metaanalysis of short-term psychodynamic psychotherapy (STPP) and cognitive-behavioural
therapy (CBT) in depression (1); the conclusions seem to support Dr Abasss
call to reconsider the STPP evidence base. In our review of psychodynamic
psychotherapy (2), we acknowledged 2 metaanalyses of brief dynamic psychotherapy
and STDP (3,4), but we indicated our concern that in both instances, interpersonal
psychotherapy (IPT) was included within the broader term, brief dynamic
psychotherapy.
Unfortunately, this practice is repeated in Leichsenrings review.
Statistical approaches like metaanalysis use the principle of aggregation
to their advantage to pool findings from a range of research settings.
However, unless there is consistency within the category across which
information is being pooled, this singular advantage can become a liability.
When effect sizes for STPP are calculated in part from the efficacy of
treatments not placed within this category, the true magnitude of STPPs
effect is obscured. With respect to the point under discussion, Markowitz,
Svartberg and Swartz have affirmed that IPT is distinct from STPP
(5).
In Leichsenrings review, 6 studies meet the authors inclusion
criteria, which include a minimum of 11 sessions, with in all cases a
focus on specific conflicts or themes. Again, the author includes
IPT in 1 of the eligible 6 studies; a further 2 of the remaining 5 are
follow-up reports (6,7). Dr Abbass cites a series of references (his references
311) as controlled trials for patients with depression. In fact,
these references deal with subsyndromal depression (8) and depression
in elderly populations (9,10) and, again, refer frequently to psychodynamic
interpersonal psychotherapy (7,11). Dr Abbass also cites several
studies dealing with short-term psychotherapy of personality disorders
(1214).
We agree with Leichsenrings conclusion that to date, there
are no 2 studies by independent research groups demonstrating equal effectiveness
of the same form of STPP compared to CBT/BT in the treatment of depression
. . . further study should focus on specific versions of STPP rather than
a broadly defined model of STPP.
A more rigorous definition of STPP, together with replicated clinical
trials involving comparable manual-driven approaches to therapy, would
allow this form of psychotherapy to be recommended with a higher level
of evidence.
Thank you for allowing us to respond to this important issue.
References
1. Leichsenring F. Comparative effects of short-term dynamic
psychodynamic psychotherapy and cognitive-behavior therapy in depression:
a meta-analytic approach. Clin Psychol Rev 2001;21:40119.
2. Kennedy SH, Lam R. Clinical guidelines for the treatment of depression.
Can J Psychiatry 2001;46 (Suppl 1):32S.
3. Crits-Christoph P. The efficacy of brief dynamic
psychotherapy: a meta-analysis. Am J Psychiatry 1992; 149:1518.
4. Anderson E, Lambert M. Short-term dynamically
oriented psychotherapy: a review and meta-analysis. Clin Psychol Rev 1995;15:50314.
5. Markowitz JC, Svartberg M, Swartz HA. Is IPT
time-limited psychodynamic psychotherapy? J Psychother Pract Res 1998;
7:18595.
6. Gallagher RM. Training issues at the interface
between consultation-liaison psychiatry and behavioural medicine. Adv
Psychosom Med. 1990; 20:3352.
7. Shapiro DA, Rees A, Barkham M, Hardy G, Reynolds
S, Startup M. Effects of treatment duration and severity of depression
on the maintenance of gains after cognitive-behavioral and psychodynamic-interpersonal
psychotherapy. J Consult Clin Psychol 1995;63:37887.
8. Barkham M, Shapiro DA, Hardy GE, Rees A. Psychotherapy
in two-plus-one sessions: outcomes of a randomized controlled trial of
cognitive-behavioral and psychodynamic-interpersonal therapy for subsyndromal
depression. J Consult Clin Psychol 1999;67:20111.
9. Gallagher DE, Thompson LW. Treatment of major
depressive disorder in older adult outpatients with brief psychotherapies.
Psychotherapy: Theory, Research and Practice 1982;19:48290.
10. Thompson LW, Gallagher D, Steinmentz Breckenridge
J. Comparative effectiveness of psychotherapies for depressed elders.
J Consult Clin Psychol 1983;55:38590.
11. Shapiro DA, Barkham M, Rees A, Hardy GE, Reynolds
S, Startup M. Effects of treatment duration and severity of depression
on the effectiveness of cognitive-behavioral and psychodynamic-interpersonal
psychotherapy. J Consult Clin Psychol 1994;62:52234.
12. Winston A, Laikin M, Pollack J, Wallner Samstag
L, McCullough L, Muran C. Short-term psychotherapy of personality disorders.
Am J Psychiatry 1993;151:1904.
13. Winston A, Pollack J, McCullough L, Flegenheimer
W, Kestenbaum R, Trujillo M. Brief psychotherapy of personality disorders.
J Nerv Ment Dis 1991;179:18893.
14. Andreoli A, Frances A, Gex-Fabry M, Aapro N,
Gerin P, Dazord A. Crisis intervention in depressed patients with and
without DSM-III-R personality disorders. J Nerv Ment Dis 1993;181:7327.
Sidney H Kennedy, MD, FRCPC
Zindel V Segal, PhD, C Psych
Toronto, Ontario
Raymond W Lam, MD, FRCPC
Vancouver, British Columbia
Diane K Whitney, MD, FRCPC
London, Ontario
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