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Editorial
Mood DisordersNew
Definitions, New Treament Directions
Paul Grof
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In Review
"Cade's
Disease" and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed
Definition for Bipolar Spectrum Disorder
S Nassir Ghaemi,
James Y Ko, Frederick K Goodwin
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The Neurobiology
of Bipolar Disorder: Focus on Signal Transduction Pathways and the
Regulation of Gene Expression
Yarema Bezchlibnyk, L Trevor Young
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Original
Research
Major Depression
and Its Association With Long-Term Medical Conditions
Lisa M Gagnon, Scott B Patten
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Seasonal Affective
Disorders: Relevance of Icelandic and Icelandic-Canadian Evidence
to Etiologic Hypotheses
Jóhann Axelsson, Jón G Stefànsson,
Andrés Magnússon, Helgi Sigvaldason, Mikael M Karlsson
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Canadian Psychiatric
Inpatient Religious Commitment: An Association With Mental Health
Marilyn Baetz, David B Larson, Gene Marcoux, Rudy
Bowen, Ron Griffin
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The
Moderating Effects of Coping Strategies on Major Depression in the
General Population
JianLi Wang, Scott B Patten
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Antidepressant
Side Effects in Depression Patients Treated in A Naturalistic Setting:
A Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine
JD Vanderkooy, Sidney H Kennedy, R Michael Bagby
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Treatment
Delays for Involuntary Psychiatric Patients Associated With Reviews
of Treatment Capacity
Michelle Kelly, Sandra Dunbar, John E Gray, Richard
L O'Reilly
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Book Reviews
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Books Received
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Letters to the Editor
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Letters to the Editor
Short-Term Dynamic Psychotherapies in the Treatment of Major Depression
Dear Editor:
I commend the excellent work of Dr Kennedy, Dr Lam, and the working group
that provided the Clinical Guidelines for the Treatment of Depressive
Disorders (1). This letter is to provide updated information from a systematic
review of short-term dynamic psychotherapies (STDPs) currently being conducted
under the Cochrane Collaboration (2) and to demonstrate that converging
data now support STDP as a valid first-line treatment for depression.
Although their first point is that few published trials exist, we have
found over 40 published controlled trials of STDP, including 9 studies
assessing 888 patients with depression (311). This represents at
least 20 more studies than Anderson and Lamberts review (12) which,
unlike our review, included studies of interpersonal therapy (IPT). Further,
4 of these studies included patients diagnosed with personality disorders
treated with Davanloos version of STDP (intensive STDP), with one-third
of the samples having comorbid depression or dysthymic disorder (1316).
Another study examined patients with personality disorders and depression
or anxiety disorders (17).
In terms of relative efficacy, a recent review showed STDP to be as effective
as cognitive-behavioural therapy (CBT) for reducing symptoms in patients
with depression (18). In one head-to-head study, ISTDP outperformed a
more cognitive dynamic treatment on the depression subscale
of the Symptom Checklist-90 (SCL-90) with an effect size of 1.35 (15).
STDPs appear to have a broad applicability, with studies showing efficacy
in patients with personality disorders and depression or dysthymic disorder,
as noted above. Conversely, the National Institutes of Mental Health (NIMH)
depression study identified limitations in both CBT and IPT treatment
for patients with personality disorders (19).
The authors point out the wide use of psychodynamic psychotherapy
in clinical practice(1, p 32S). According to the authors, then,
psychodynamic models are many clinicians primary instruments, with
or without training in newer, empirically validated brief psychodynamic
therapies.
When one combines these practice patterns with the substantial number
of newer controlled trials showing efficacy, the demonstrated equal efficacy
with CBT, and the broad scope of applicability, one has to consider variants
of STDPs as potential first-line treatments of depression.
References
1. Kennedy SH, Lam R Clinical guidelines for the treatment
of depression. Can J Psychiatry 2001;46 (Suppl 1).
2. Abbass A. A systematic review of short term psychodynamic
psychotherapies. Proceedings of The 8th International Cochrane Colloquium;
October 2529, 2000; Cape Town (SA).
3. Barkham M., Shapiro DA, Hardy GE, Rees A. Psychotherapy
in two-plus-one sessions: outcomes of a randomized controlled trial of
cognitive-behavioral and psychodynamic-interpersonal therapy for subsyndromal
depression. J Consult Clin Psychol 1999;67: 20111.
4. Gallagher DE, Thompson LW. Treatment of major
depressive disorder in older adult outpatients with brief psychotherapies.
Psychotherapy: Theory, Research and Practice 1982;19:48290.
5. Thompson LW, Gallagher D, Steinmentz Breckenridge
J. Comparative effectiveness of psychotherapies for depressed elders.
J Consult Clin Psychol 1983;55:38590.
6. Hersen M, Bellack AS, Himmelhoch JM, Thase ME.
Effects of social skill training, amitriptyline, and psychotherapy in
unipolar depressed women. Behavior Therapy 1984;15:2140.
7. McLean PD, Hakstian AR. Clinical depression:
comparative efficacy of outpatient treatments. J Consult Clin Psychol
1979;47:81836.
8. Reynolds S, Stiles WB, Barkham M, Shapiro DA,
Hardy G, Rees A. Acceleration of changes in session impact during contrasting
time-limited psychotherapies. J Consult Clin Psychol 1996;64:57786.
9. Shapiro DA, Barkham M, Rees A, Hardy GE, Reynolds
S, Startup M. Effects of treatment duration and severity of depression
on the effectiveness of cognitive-behavioral and psychodynamic-interpersonal
psychotherapy. J Consult Clin Psychol 1994;62:52234.
10. Shapiro DA, Rees A, Barkham M, Hardy G, Reynolds
S, Startup M. Effects of treatment duration and severity of depression
on the maintenance of gains after cognitive-behavioral and psychodynamic-interpersonal
psychotherapy. J Consult Clin Psychol 1995;63:37887.
11. Shapiro DA, Firth J. Prescriptive v. explorative
psychotherapy: outcomes of the Sheffield psychotherapy project. Br J Psychiatry
1987;151:7909.
12. Anderson E, Lambert M. Short-term dynamically
oriented psychotherapy: a review and meta-analysis. Clin Psychol Rev 1995;15:50314.
13. Hellerstein DJ, Rosenthal RN, Pinsker H, Samstag
LW, Muran JC, Winston A. A randomized prospective study comparing supportive
and dynamic therapies. J Psychother Pract Res 1998;7:26171.
14. Winston A, Laikin M, Pollack J, Wallner Samstag
L, McCullough L, Muran C. Short-term psychotherapy of personality disorders.
Am J Psychiatry 1993;151:1904.
15. Winston A, Pollack J, McCullough L, Flegenheimer
W, Kestenbaum R, Trujillo M. Brief psychotherapy of personality disorders.
J Nerv Ment Dis 1991;179:18893.
16. Abbass A. A multicentre controlled evaluation
of short-term dynamic psychotherapy of patients with personality disorders.
Proceedings of the Canadian Psychiatric Association Annual Meeting; October,
2000; Victoria (BC).
17. Andreoli A, Frances A, Gex-Fabry M, Aapro N,
Gerin P, Dazord A. Crisis intervention in depressed patients with and
without DSM-III-R personality disorders. J Nerv Ment Dis 1993;181:7327.
18. Leichsenring F. Comparative effects of short-term
dynamic psychodynamic psychotherapy and cognitive-behavior therapy in
depression: a meta-analytic approach. Clin Psychol Rev 2001;21:40119.
19. Shea MT. Psychosocial treatment of personality
disorders. J Personal Disord 1993; (Suppl):16780.
Allan Abbass, MD, FRCPC
Halifax, Nova Scotia
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